The onlymain reason to add the burton salts to the mash would be to adjust the pH, and secondly to impart a more assertive hop bitterness. Generally itthe salts will lower the pH itif it's just comprised of Gypsum, but it really depends upon the composition.
After adding the malts, test the mash with a pH meter - if it's well over 5.2pH, then add increments of 5g of the burton salts until the pH is around 5.1-5.3pH. If it's well under, then add baking soda or chalk until the pH is in the right level. (You can also try chalk, but it's almost insoluble so quite difficult to use.)
If you don't have a pH meter, then I would still add the salts and, plus some baking soda if you have dark malts, since they are likely needed to provide somewhich provides buffering capacity in the water against any dark malts in the grist.